Ms. Nancy Lachner | Australian Centre for Ecogenomics

Ms. Nancy Lachner

Clinical Program Coordinator

n.lachner@uq.edu.au

Centre research
Publications

Extracting genomes of uncultured members of the human microbiome

An important aspect of our work with host-associated microbiomes involves investigating members of these communities that have yet to be cultured within the laboratory.

Understanding the contribution of the microbiome to the development of GVHD

Bone marrow and stem cell transplants are important therapies for cancers such as leukemia, lymphoma and myeloma that develop in blood forming tissues.

Modifying the microbiome for treatment of COPD

Chronic obstructive pulmonary disease (COPD) is used to describe a number of lung diseases that prevent proper breathing.

Determinants of the Progression of Actinic Keratosis to Squamous Cell Skin Cancer

Squamous cell carcinoma (SCC) is the second most common form of skin cancer globally.

2020

Bowerman KL, Varelias A, Lachner N, Kuns RD, Hill GR, Hugenholtz P. 2020. Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice. Gut Microbes. :1-17.

2019

Rehaume LM, Matigian N, Mehdi AM, Lachner N, Bowerman KL, Daly JN, Cao K-ALê, Hugenholtz P, Thomas R. 2019. IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiotaObjectivesMethodsResultsConclusions. Annals of the Rheumatic Diseases. 78(4):494-503.

2018

Wood DLA, Lachner N, Tan J-M, Tang S, Angel N, Laino A, Linedale R, Cao K-ALê, Morrison M, Frazer IH et al.. 2018. A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes. mBio. 9(5)

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L et al.. 2018. Recipient mucosal-associated invariant T cells control GVHD within the colon. Journal of Clinical Investigation. 128(5):1919-1936.

Schofield B.J., Lachner N, Le O.T., McNeill D.M., Dart P., Ouwerkerk D., Hugenholtz P., Klieve A.V.. 2018. Beneficial changes in rumen bacterial community profile in sheep and dairy calves as a result of feeding the probiotic Bacillus amyloliquefaciens H57. Journal of Applied Microbiology. 124(3):855-866.

2017

Varelias A, Ormerod KL, Bunting MD, Koyama M, Gartlan KH, Kuns RD, Lachner N, Locke KR, Lim CY, Henden AS et al.. 2017. Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Blood.

2016

Schofield BJ, Skarshewski A, Lachner N, Ouwerkerk D, Klieve AV, Dart P, Hugenholtz P. 2016. Near complete genome sequence of the animal feed probiotic, Bacillus amyloliquefaciens H57. Standards in Genomic Sciences. 11(1)

Ormerod KL, Wood DLA, Lachner N, Gellatly SL, Daly JN, Parsons JD, Dal’Molin CGO, Palfreyman RW, Nielsen LK, Cooper MA et al.. 2016. Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals. Microbiome. 4(1)

2013

Willner DL, Hugenholtz P, Yerkovich ST, Tan ME, Daly JN, Lachner N, Hopkins PM, Chambers DC. 2013. Re-Establishment of Recipient-Associated Microbiota in the Lung Allograft is Linked to Reduced Risk of Bronchiolitis Obliterans Syndrome.. American journal of respiratory and critical care medicine.

Haroon MF, Skennerton CT, Steen JA, Lachner N, Hugenholtz P, Tyson GW. 2013. In-solution fluorescence in situ hybridization and fluorescence-activated cell sorting for single cell and population genome recovery.. Methods in enzymology. 531:3-19.

Last reviewed 11 January 2019

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Level 5, Molecular Biosciences Bldg
University of Queensland
ST LUCIA QLD 4072
Brisbane, Australia

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