Our method for experimental testing of a phage host-range without the need for culturing the host has been just published in Nature Microbiology. It involves fluorescent staining of anonymous phages collected from an environment which are combined with anonymous environmental bacteria, and the subset of bacteria tagged by fluorescent viruses is collected by fluorescence activated cells sorting and analysed on single-cell level. This "viral tagging" method has been demonstrated on human gut microbiome to explore possible interactions between phages and their hosts coming from different human volunteers which can have implications for faecal microbiota transplant therapy. The resulting host-phage network revealed hosts for hundreds of previously unknown viruses and it showed that the phages are mostly species-specific (and not strain-specific as previously though), and only a smaller number of phages have a wider host-range. In addition, we found out that the phages in the human gut have possibly low burst sizes and that the prophage induction in the gut is common, thus the phages do not perturb the human gut microbiome composition heavily on a daily basis.
ACE members Soo Jen Low, Mária Džunková, Pierre-Alain Chaumeil, Donovan Parks and Philip Hugenholtz published "Evaluation of a concatenated protein phylogeny for classification of tailed double-stranded DNA viruses belonging to the order Caudovirales" in Nature Microbiology.
We have an exciting PhD opportunity (stipend included) available at ACE starting in July working on non-photosynthetic Cyanobacteria using metagenomics, culturing and cryo-EM with Dr. Rochelle Soo and Prof. Phil Hugenholtz. For more details contact Dr Rochelle Soo – firstname.lastname@example.org. Please include a copy of your CV and academic transcript.
ACE members Paul Evans, Joel Boyd, Andy Leu, Ben Woodcroft, Donovan Parks, Philip Hugenholtz and Gene Tyson published "An evolving view of methane metabolism in the Archaea" in Nature Reviews Microbiology.
Clarivate Analytics' annually published list recognizes world-class researchers selected for their exceptional research performance, demonstrated by production of multiple highly cited papers that rank in the top 1% by citations for field and year in Web of Science.
The Australian Research Council's (ARC) Discovery Early Career Researcher Award (DECRA) recognizes promising early career researchers and provides them with up to three years of support. It is a highly competitive award, with only 200 being awarded nationwide. Congratulations Rochelle!
ACE members Donovan Parks, Christian Rinke, Maria Chuvochina, Pierre-Alain Chaumeil, Ben Woodcroft, Paul Evans, Philip Hugenholtz and Gene Tyson published 8000 new metagenome-assembled genomes (MAGs) in Nature Microbiology, substantially expanding the tree of life.