TitleGenome sequences of rare, uncultured bacteria obtained by differential coverage binning of multiple metagenomes.
Publication TypeJournal Article
Year of Publication2013
AuthorsAlbertsen M, Hugenholtz P, Skarshewski A, Nielsen KL, Tyson GW, Nielsen PH
JournalNature biotechnology
Volume31
Pagination533-8
Date Published2013 Jun
ISSN1546-1696
AbstractReference genomes are required to understand the diverse roles of microorganisms in ecology, evolution, human and animal health, but most species remain uncultured. Here we present a sequence composition-independent approach to recover high-quality microbial genomes from deeply sequenced metagenomes. Multiple metagenomes of the same community, which differ in relative population abundances, were used to assemble 31 bacterial genomes, including rare (
DOI10.1038/nbt.2579

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